Mammography Screening: Efficacy, Benefits, and Harms
Researcher: My Catarina von Euler-Chelpin
Focus: Public Health
DIS Location: Copenhagen
Starting: Fall 2018
About the Research:
Mammography screening for early detection of breast cancer is offered in most European countries, as well as in the U.S. Breast density has turned out to be one of the more significant risk factors for breast cancer. Efforts have been put into studying the possibility of adding computer assisted diagnostics (CAD) for automated breast density analysis and cancer detection, but also to the possibility of using computer assistance in breast parenchymal texture analysis (i.e. other patterns than density and the associated risk of breast cancer).
In order to assess whether screening works differently in women with different types of breasts in terms of density and texture, we are currently using data from the Capital Region mammography program, Denmark. We are comparing the sensitivity and specificity for the different density and pattern measures and evaluating the positive predictive value. We will also be evaluating the relative risk of being true positive classifying the women by radiology assessed BI-RADS density, using both chi-square and logistic regression as a method of analysis. The project will also be working with at least one other European collaborator and their data.
With this background, and within the realm of more personalized screening, the Research Assistant will collaborate with a senior researcher in a project studying recent data from mammography programs with the aim of assessing measures of quality assurance in relation to varying density in populations at national and regional levels.
Learning Objectives include:
- Studying the current state of screening on a European level
- Keeping in contact with other researchers at a national and international level (e.g. academic counterparts at other universities or research institutions)
- Aggregating and analyzing data
- Writing briefs and collaborating in writing articles
- Generally participating in the day-to-day research process
- Some travel should be expected
Whenever possible, the aim is to enable the Research Assistant to produce enough academic work, so as to be a co-author of a peer-reviewed publication.
My von Euler-Chelpin (Ph.D. – University of Copenhagen) is an Associate professor in Epidemiology at the Department of Public Health at the University of Copenhagen. She does register research mainly into programs of breast cancer screening, long and short-term outcomes and evaluating harms and benefits. She has collaborated with Group Health Research Institute (GHRI) in Seattle, Network on Health Services in Chronic Diseases (REDISSEC), Barcelona and Department of Molecular medicine and Surgery at Karolinska Institutet, Stockholm. Most recently she is studying the possibilities of different imaging procedures in relation to determining breast density, an important risk factor for breast cancer, in collaboration with the Department of Computer Science at the University of Copenhagen. She also holds a degree in Social Science, from University of Stockholm, and has earlier done register-based research at Statistics Sweden, UNESCO, Paris and Nairobi, and as a consultant for e.g. EU, Unifem, and the International Committee of the Red Cross (ICRC).