Dianox develops novel oligonucleotides called chemical antibodies or aptamers that can bind to proteins, small molecules, or cells with high affinity. We have developed a proprietary database and machine learning platform to create new aptamers that can bind to different targets. The research project will encompass binding of aptamers to surface proteins related to cancer. The research assistant will test these aptamers using fluorescence and other techniques on proteins or cancer cells lines. Over the course of the term, the research assistant will do weekly one-pagers and finalize the project by writing up a research paper.
Please note: This course will require a lot of reading in the beginning of the semester in order to understand the fundamentals of the research
Select Research Mentor bibliography:
- Jahromi BR, Zamorin, V, Code C, Netti E, Laaskso A, Tulamo R, Niemelä M (2022). E-149 Contrast labeled immunoliposomes for detecting rupture prone aneurysms. Brain and Spine (2). http://dx.doi.org/10.1136/neurintsurg-2022-SNIS.260
- da Silva AG, Goulart L, Loffler P, Code C, Neves Al (2022). Development of a Molecular Aptamer Beacon Applied to Magnetic-Assisted RNA Extraction for Detection of Dengue and Zika Viruses Using Clinical Samples. International Journal of Molecular Sciences (22). https://doi.org/10.3390/ijms232213866
Related Discipline(s)
This course would also be of interest to the following discipline(s):Chemistry / Biochemistry, Pre-Medicine / Health Science
