In our aging society more and more people suffer from neurodegenerative diseases such as Alzheimer’s disease (AD). Decades of research have focused on mouse models, but all drug candidates which have successfully treated AD in mice have failed in human clinical trials. In order to address these pressing needs, human models such as neurons, astrocytes, and microglia derived from induced pluripotent stem cells are the key. In combination with gene editing using CRISPR-Cas9 these cellular models provide insights into early disease development and progression in the species we need to investigate: humans.
PhD at Max Planck Institute for Molecular Genetics and Free University, Berlin, Germany in Human Genetics (2005). Postdoctoral Research Fellow at UC Irvine, CA, USA (2005-2011) Postdoctoral Researcher (2012-2014) University Copenhagen. MSc at Robert Koch Institute and Free University, Berlin, Germany, in 2001 working with Mycobacteria. Assistant Professor (2014-2015) University Copenhagen. Associate Professor (2015-present) University Copenhagen. With DIS since 2016.