Location: Psychiatric Center Copenhagen, Copenhagen University Hospital, Rigshospitalet
Research topic: Bipolar disorder is associated with a wide range of neurobiological disturbances, including anomalies in the structure and function of cortical and subcortical brain regions. Recent studies have shown that many of these abnormalities are also present in never-depressed offspring of adults suffering from depression who are at increased risk of onset of this disorder. Identifying neurobiological changes in these individuals at high familial risk can provide a neural marker of depression risk and may facilitate the development of targeted strategies for the prevention and treatment of major depression.
What you will work with: The project is planned to involve visual assessment of the quality of MRI brain scans and brain models automatically constructed by the Freesurfer software and correct errors in the reconstruction. In addition, the project may also involve exploring recent neuroimaging literature in bipolar disorder and high-risk participants and summarizing these findings in a working document.