Lars Jørn Jensen’s group (Cerebrovascular Physiology) studies arteriolar function in health and disease. We investigate fundamental mechanisms in regulation of arteriolar tone involved in the control of blood pressure and organ perfusion (with emphasis on the brain). We specialize in myogenic tone, flow-mediated vasodilatation, and structural remodeling, which are key determinants of vascular function in vivo. We strive to describe new molecular mechanisms, and to apply this research using animal models of hypertension, aging, obesity, and diabetes. In collaboration with the LifePharm In Vivo Pharmacology Centre (UCPH), we assist in development of porcine models of obesity and diabetes through our expertise in microvascular function.
Research Institution: University of Copenhagen