About this course
The complex cellular and molecular organization of the brain drives a variety of physiological and cognitive functions. In this course, we explore gene expression and protein distribution on the level of organ, brain region, and cell. We utilize data and resources from the human protein atlas project and other publicly available data sets to learn the advantages and limitations of different approaches, validate results, and utilize the available complementary data to link genes to cells and cellular processes involved in ‘normal’ physiology or disease.
Syllabus
Pre-requisites
One year of either biology or neuroscience, and one course in either molecular biology or genetics, all at university level.
Faculty
Jan Mulder
FacultyPhD in molecular neurobiology (Rijksuniversiteit Groningen, 2005), MSc in biology (Rijksuniversiteit Groningen, 2000). Senior researcher and group leader at Science for Life laboratory, department of Neuroscience, Karolinska Institute since 2010. Group leader of the brain profiling efforts within the Human Protein Atlas project since 2010. Research in identifying the cellular location of proteins linked to brain function and disease. With DIS since 2017.
Nicholas Mitsios
FacultyBSc in Molecular Biology (Liverpool, 1998) and PhD in Molecular Biology of Ischemic Stroke (Manchester, 2005). Currently a researcher at the Department of Neuroscience, Karolinska Institute and the Brain Profiling sub-unit of the Human Protein Atlas (HPA) project since 2011. Research focuses on the central nervous systems of mammals, with an emphasis on the identification of proteins involved in brain normal development and pathophysiology. With DIS since 2020.